From the TCM perspective, pustular psoriasis often manifests as "heart fire flaring"—a state of yang excess disrupting the yin-yang balance. Clinically, this correlates with modern observations of cardiovascular hyperactivity: elevated heart rate variability, disrupted circadian cortisol rhythms, and increased oxidative stress in epidermal cells. Patients frequently report a burning sensation in affected areas, akin to the "internal heat" described in classical texts, accompanied by insomnia and metabolic inefficiency. The skin's role as an endocrine organ becomes evident when pustules form, reflecting systemic inflammation rooted in autonomic nervous system dysregulation.

Modern dermatology identifies IL-17/IL-23 axis overactivation as key pathology, while TCM attributes similar phenomena to "damp-heat accumulation" obstructing meridian flow. Clinical studies show 68% of patients exhibit elevated sympathetic nervous system tone, mirroring TCM's "shen disturbance" diagnosis. Therapeutic approaches must therefore address both dimensions: cooling heart fire through herbs like dandelion and honeysuckle while modulating Th17 cells with biologic agents; restoring yin via acupuncture at Pericardium-6 to calm the vagus nerve, paired with omega-3 supplementation to reduce inflammatory cytokines. Sleep quality emerges as critical—deep sleep phases directly suppress pro-inflammatory NF-κB pathways, creating a therapeutic window for skin regeneration.